Rare acute leukemia of ambiguous lineage in which the blasts do not express markers specific to myeloid or lymphoid lineage.
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A mouse model of human ZNF198-fibroblast growth factor receptor-1 (FGFR1) stem cell leukemia lymphoma has been developed to investigate mechanisms of oncogenesis and progression.
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This group of patients is supplemented in addition by non- and lateresponders and children with acute undifferentiated leukemia (AUL).
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These cells are thought to be responsible for relapse and are termed leukemia stem cells (LSCs).
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Leukemia progression and relapse is fueled by leukemia stem cells (LSC) that are resistant to current treatments.
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Specific identification of leukemia stem cells and their discrimination from normal hematopoietic stem cells would greatly contribute to risk stratification and could predict possible relapses.